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BrightFocus-funded researchers were among the first to “map” the normal 3D structure of a protein called myocilin, which is abundant in the drainage pathway of the eye. Now, with a second grant, they’ve designed antibodies to help diagnose and treat myocilin misfolding as it contributes to glaucoma.
BrightFocus-funded researchers crosslink exfoliation syndrome (XFS), a condition that can lead to glaucoma, with common comorbidities and shared risk factors as a way of predicting which patients are at increased risk.
After early human development, the nerve cells of the eye no longer regenerate. Researchers are looking for ways to genetically manipulate this pathway to protect and repair damaged retinal ganglion cells in glaucoma.
Gene found to regulate tissue responsible for draining fluid from the eye.
Learn about a key lifestyle change that could help decrease your risk for developing the devastating eye disease
Learn about an implantable wireless device has identified new ways to help physicians diagnose and monitor glaucoma.
Learn about the first successful attempt to transplant lab-grown retinal ganglion cells (RGCs) into the eyes of mice to find a cure for glaucoma.
Recently, when their groundbreaking genetics discovery was featured on the cover of Nature, the research team thanked BrightFocus for critical early funding that supported their accomplishments.
An interdisciplinary team of Harvard scientists has successfully reprogrammed cells in mice to reverse vision loss from glaucoma, as well as normal (not disease-related) vision loss associated with aging in mouse models.
