The role of Centaurin-α1 in Alzheimer’s Disease Pathology

Summary

It is thought that Alzheimer’s disease (AD) is caused by accumulation of beta amyloid (Aβ) in the brain. We recently identified that a signaling protein called centaurin-α1 (CentA1) causes Aβ -induced dysfunction of neurons and thus potentially contributes to brain dysfunction in AD. In this project, we will further study the potential roles of CentA1 in AD using newly developed CentA1 knockout mice in combination with the mouse model for Alzheimer’s disease. We hope that this will lead to new therapeutics for AD targeting CentA1.