Alzheimer's Disease, Before Plaques And Tangles

Summary

In this application, we propose to study the postmortem brain of individuals between 30 and 50 years of age and to identify those brains with the very early pathologic changes or lesions of Alzheimer’s disease. Then, we will study whether these lesions are associated with other abnormalities and whether they cause degeneration and death of brain nerve cells.  Information obtained from this study could eventually help the development of new diagnostic tests and treatments for Alzheimer’s disease.