Dementia and Depression

Learn about the relationship between depression and dementia, and about potential treatment options for depression.

A Frequent Problem

Among people with dementia, depression is a frequent additional problem and one that can greatly diminish quality of life for both patient and care partner. Depression is especially common in people with vascular dementia but also affects many with Alzheimer’s disease. Overall, one recent analysis estimated that one in six people with dementia suffers from major depressive disorder. Milder but significant symptoms are even more common. In nursing home residents with dementia, the rates are even higher.

Is Depression the First Sign?

Researchers and clinicians have been thinking for a long time about the relationship between depression and dementia. Sometimes, depressive symptoms are the first glimpse of the brain failure that will lead to dementia. Some researchers believe that depression increases inflammation and other chemical changes in the body, actually increasing the risk of later dementia. Everyone agrees that depression and dementia together create more suffering and complications than either condition alone.

An Accurate Diagnosis is Crucial

When depression accompanies dementia, identifying and treating it can potentially make life better for patient and care partner. However, finding depression is not always easy. Other conditions create symptoms that look like depression, misleading family and clinicians. Medical problems like low thyroid, some cancers, or sleep apnea sometimes create depression-like symptoms that take attention away from a medical problem that needs its own treatment. One recent study, too, pointed out the importance of attending to manageable factors in the patient’s living conditions. For example, physical pain and social isolation are important contributors to depression in people who are cognitively impaired, and they can be addressed.

A common symptom of dementia is apathy, the loss of initiative and motivation. Apathy is even more common than depression in people with dementia, but it doesn’t respond the same way to antidepressant treatment. In fact, some of the antidepressants can increase apathy, but a helpful clinician might not consider that possibility in a person who is withdrawn and fatigued. Apathy is not necessarily linked with sadness or suicidal feelings, so Owen’s comment about ending his life suggests that depression rather than apathy may be important in his case.

Understanding the Obstacles: Diminished Insight

A further obstacle to recognizing depression in a person with dementia occurs when diminished insight interferes with a person’s ability to recognize or describe their emotions. A person with dementia and depression may feel desperate and yet be unable to express sadness in words. Delusional fears, agitation or withdrawal, or aggressive or suicidal behavior may be the most noticeable signs of depression in that person.

Treatment

Antidepressants

There is much controversy about how best to treat depression in a person with dementia. The cognitive-enhancing medications (cholinesterase inhibitors and memantine) don’t seem to have significant value in treating depression.

Among the many studies of antidepressant medications used for this purpose, the majority have not shown medication to be better than placebo.

Many experienced clinicians and some of the research, though, claim that an antidepressant trial is worth undertaking when depressive symptoms are typical of major depressive disorder. Some antidepressants, too, reduce agitation that may represent disguised depression.

The important point is to watch for adverse effects or lack of response and stop the medication if that is clinically appropriate. Antidepressant doses should start low and be increased cautiously, but it’s important not to under-dose, which can interfere with effectiveness. If the medication seems to help, it may be appropriate to try tapering and to stop the antidepressant once depressive symptoms have been absent for six months or more. Periodic re-evaluation of the need for an antidepressant is helpful in reducing unnecessary pharmacotherapy. Discontinuing an antidepressant should be gradual when that’s possible. When done too quickly, discontinuation symptoms can be unpleasant. Some patients do best with ongoing maintenance therapy to prevent the return of depressive symptoms. The pros and cons of continuing therapy need to be considered for each individual.

Psychotherapy

Families often ask about psychotherapy for depression. Psychotherapy’s value can be difficult to assess when advancing dementia interferes with understanding and memory.

Insight-oriented psychotherapy may be especially useful during the earlier stages of cognitive impairment.

Other Forms of Therapy

Later on, a person with dementia may find it more comforting to participate in reminiscence therapy, behavioral activation, music therapy, or other non-medication approaches that emphasize group interaction and relaxation.

Caring for the Caregivers

A final consideration regarding dementia and depression concerns care partners of people with dementia. Caregiving is a stressful responsibility and increases the risk of depression for the caregiver. One recent report found that more than two of every three caregivers scored high on a test of depression. The risk for depression was greater among caregivers who were older, or had attained a lower educational level, or had less support from other family members.

Depression risk was also increased when the severity of dementia was greater in the care recipient. A healthier care partner will enjoy a better quality of life and will also have more to offer the care recipient.