The Role of the Immune System in Alzheimer's Disease

The research of this project will characterize and validate a peripheral immune mechanism that contributes to Alzheimer’s pathology in human samples, which could offer important biomarkers for the diagnosis of the disease and the design of new therapies.

Alzheimer’s disease has traditionally been considered a neuronal pathology, but now it is known that a specific type of brain immune cell, called microglia, plays a crucial role in the pathogenesis of the disease. This project aims to understand how immune cells from the blood impact microglia and contribute to the development of Alzheimer’s disease.

This project will use human samples, enabling researchers to obtain potential translational results for the clinic. The characterization and validation of a peripheral immune mechanism that contributes to Alzheimer’s pathology could offer important biomarkers for disease diagnosis and the design of new therapies.

It is known that a specific type of brain immune cell, called microglia, plays a crucial role in the pathogenesis of Alzheimer’s disease. This project aims to understand how immune cells from the blood impact microglia and contribute to the development of Alzheimer’s. The characterization and validation of a peripheral immune mechanism that contributes to Alzheimer’s pathology could offer important biomarkers for disease diagnosis and the design of new therapies.

The contribution of the peripheral immune system in Alzheimer’s disease has been poorly explored. This project aims to fill the gap in understanding the potential communication between specific disease-related blood immune cells and microglia during the development of the disease using human samples and innovative humanized animal models.

The research of this project will be conducted using human samples, enabling to obtain potential translational results for the clinic. The characterization and validation of a peripheral immune mechanism that contributes to AD pathology could offer important biomarkers for the diagnosis of the disease and the design of new therapies.