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Grants > Neurotrophin Signaling in the Human Trabecular Meshwork Updated On: Ene. 23, 2025
National Glaucoma Research Grant

Neurotrophin Signaling in the Human Trabecular Meshwork

Principal Investigator

Robert Wordinger, PhD

University of North Texas Health Science Center

Fort Worth, TX, USA

About the Research Project

Program

National Glaucoma Research

Award Type

Standard

Award Amount

$47,026

Active Dates

April 01, 1999 - March 31, 2001

Grant ID

G1999017

Summary

The trabecular meshwork is an intricate system of drainage canals through which the intraocular fluid, also called the aqueous humor, drains from the eye. This drainage helps the eye maintain normal fluid pressure. Dr. Wordinger has hypothesized that a certain class of growth factors, called neurotrophins, play an important role in cells of the trabecular meshwork (TM). He hopes to improve our knowledge of the normal physiology of aqueous humor outflow via the TM and to determine if neurotrophins play a role in glaucoma. If the latter proves to be true, existing compounds for regulating neurotrophins can be tested for their therapeutic value.