Characterizing Brain Angiotensin System

About the Research Project
Program
Award Type
Standard
Award Amount
$367,582
Active Dates
July 01, 2019 - June 30, 2023
Grant ID
A2019634S
Summary
This study is designed to evaluate specific factors that may play a role in development and progression of Alzheimer’s Dementia. Angiotensin receptors 1, 2 and 4 (AT1R, AT2R and AT4R) are found on brain cells and play an important function in brain vital functions. This study will examine changes in these receptors in brain cells in patients with Alzheimer’s dementia. We will also study the impact of a class of drugs that target these receptors and commonly used to treat high blood pressure.
Grants
Related Grants
Alzheimer's Disease Research
The Role of DYRK1A in Altered Microglia Biology in a Cellular Model of Alzheimer’s Disease in Down Syndrome
Active Dates
January 01, 2025 - December 31, 2027

Principal Investigator
Frances Wiseman, PhD
Current Organization
University College London (UK)
Alzheimer's Disease Research
Oxysterols in Innate and Adaptive Immunity in a Tauopathy Mouse Model
Active Dates
July 01, 2024 - June 30, 2026

Principal Investigator
Danira Toral-Rios, PhD
Current Organization
Washington University in St. Louis
Alzheimer's Disease Research
Dysregulated Astrocyte p38, Brain Inflammation, and Alzheimer's Pathology
Active Dates
July 01, 2024 - June 30, 2027

Principal Investigator
Linda Van Eldik, PhD
Current Organization
University of Kentucky Research Foundation